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Copeptin: clinical use of a new biomarker Arginine vasopressin (AVP) is a key hormone in the human body. Despite the clinical relevance of AVP in maintaining fluid balance and vascular tone, measurement of mature AVP is difficult and subject to preanalytical errors. Recently, copeptin, a 39-amino acid glycopeptide that comprises the C-termi …

Copeptin is also a marker of acute hemodynamic stress, and has been reported to aid in the prognosis or diagnosis of several cardiac disorders such as acute coronary syndrome, stable coronary artery disease, congestive heart failure, and acute ischemic stroke. copeptin in the plasma or serum of 97% of the healthy population regardless of osmolality, whereas AVP is often not detectable in plasma samples with medium or low osmolality. Probably the most relevant advantage of the copeptin assay is that copeptin, unlike mature AVP, is extremely stable in plasma or serum ex vivo. 2010-04-22 · Copeptin, the C-terminal degradation part of the vasopressin prehormone, is a stable peptide suitable as a marker for the arginine vasopressin (AVP) system (1,2), which is activated by stress and plays an essential role in osmoregulation and the control of vascular tone . Copeptin, the C-terminal part of the prohormone of vasopressin (AVP), is released together with AVP in stoichiometric concentrations reflecting an individual's stress level.

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Furthermore, vasopressin is an important hormone in salt and volume regulation. In this context, copeptin is also a diagnostic marker in patients with diabetes insipidus and in patients with disordered water states. Copeptin is the C terminal peptide of proAVP and is co-secreted on an equimolar basis with AVP from the posterior pituitary. Arginine vasopressin (AVP), also known as antidiuretic hormone (ADH), is a hypothalamic polypeptide that is transported along the axons of the synthesizing neurons into the posterior pituitary gland. Copeptin, the C-terminal segment of the arginine vasopressin prohormone, is an arginine vasopressin surrogate with high ex vivo stability that is easy to measure. 12,15,16 In previous studies, we Copeptin, a part of the original C-terminal of arginine vasopressin (AVP), is positively correlated with AVP in the normal population and patients with cardiopulmonary and vascular diseases, and is an acute endogenous stress marker.

Copeptin frigjøres fra nevrohypofysen i ekvimolare mengder med ADH, og kan derfor brukes som en surrogat markør for ADH. Analytisk er den mere stabil, og enklere å analysere enn ADH. ADH fases ut fra 01.10.19, dvs ADH-prøver som mottas etter dette vil bli analysert for copeptin.

Copeptin has  6 May 2020 The normal range of plasma copeptin levels is from 1.0 to 13.8 pmol/l with higher median levels in men than in women according to two large  4 May 2018 To date, the temporal pattern of copeptin in cerebrospinal fluid (CSF) after aSAH is not known since copeptin levels have only been measured in  24 Jan 2017 Copeptin, the C-terminal portion of provasopressin mirrors vasopressin levels and has been described as a reliable biomarker for the individual's  17 Sep 2016 OBJECTIVE Plasma copeptin, a surrogate for vasopressin, has been associated with a decline in renal function and albuminuria in population-  18 Mar 2015 Abstract. Copeptin is a provasopressin-derived peptide, the precursor for arginine vasopressin (AVP), which is an antidiuretic hormone from the  23 Aug 2016 Chest pain patients with <6 h of symptom onset have higher copeptin levels. •.

9 Aug 2017 Copeptin (pre-proAVP) secreted in equimolar amounts with vasopressin closely reflects vasopressin release. Copeptin has been shown to 

22 Jan 2016 Copeptin (in common with bioactive peptides) is rapidly eliminated from the circulation, but not by circulating proteases.

Copeptin, the C-terminal part of the prohormone of vasopressin (AVP), is released together with AVP in stoichiometric concentrations reflecting an individual's stress level. Copeptin combined with hypersensitive cardiac troponin T (hs-cTnT) is a new detection scheme, and its value in the early diagnosis of acute myocardial infarction is still unclear. Accordingly, the aim of this study is to evaluate the diagnostic value of copeptin combined with hypersensitive troponin T detection in early acute myocardial infarction. Copeptin, part of the vasopressin prohormone, is a marker of the individual hemodynamic stress response.
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AVP has important physiological functions, including vascular tonus, the homeostasis of fluid balance and regulation of the endocrine stress response. The hypothesis suggested in the first study on the diagnostic value of copeptin for ACS, could be that endogenous stress caused by UA could be lower than in patients with AMI and could be insufficient to cause a copeptin release.

The follow-up period was 90 days. Primary and secondary outcome measures: Copeptin, troponin, myoglobin and creatine kinase values.
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Copeptin measurement has been shown to be useful in various clinical indica- tions, including the diagnosis of diabetes insipidus and the monitoring of sepsis and 

One   ADH and copeptin are released in the body in a 1:1 ratio as 2 parts of the arginine vasopressin precursor.